Varaico: Literature-Extracted Genetic Variants

Gene:PARN
Variant:p.E248del1

PARN

231 papers

RefSeq Summary

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mR...

Pfam Domains

CAF1aa 3–390UCSCCAF1 family ribonuclease
RNA_bindaa 437–515UCSCRNA binding domain

Gene Aliases

HGNC Name

poly(A)-specific ribonuclease

HGNC Alias Symbol

DAN

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_002582.4
p.E248del1
c.742_743delTTC
Surrounding Variants
3 papers
NM_002582.4
p.R249C
c.745C>T
1 paper
NM_002582.4
p.R249G
c.745C>G
1 paper
NM_002582.4
p.R249L
c.746G>T
1 paper
NM_002582.4
p.R249H
c.746G>A
1 paper
NM_002582.4
p.K250*
c.748A>T
1 paper
NM_002582.4
p.K250E
c.748A>G
1 paper
NM_002582.4
p.E247D
c.741A>T
1 paper
NM_002582.4
p.E247D
c.741A>C
1 paper
NM_002582.4
p.E247A
c.740A>C
1 paper
NM_002582.4
p.R251G
c.751A>G
4 papers
NM_002582.4
p.R251fs
c.751_752fs
1 paper
NM_002582.4
p.R251I
c.752G>T
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