Varaico: Literature-Extracted Genetic Variants

Gene:PARN
Variant:p.E246Q

PARN

231 papers

RefSeq Summary

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mR...

Pfam Domains

CAF1aa 3–390UCSCCAF1 family ribonuclease
RNA_bindaa 437–515UCSCRNA binding domain

Gene Aliases

HGNC Name

poly(A)-specific ribonuclease

HGNC Alias Symbol

DAN

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_002582.4
p.E246Q
c.736G>C
Surrounding Variants
1 paper
NM_002582.4
p.E246K
c.736G>A
1 paper
NM_002582.4
p.D245G
c.734A>G
1 paper
NM_002582.4
p.D245N
c.733G>A
1 paper
NM_002582.4
p.E247A
c.740A>C
1 paper
NM_002582.4
p.V244A
c.731T>C
1 paper
NM_002582.4
p.E247D
c.741A>T
1 paper
NM_002582.4
p.E247D
c.741A>C
3 papers
NM_002582.4
p.R249C
c.745C>T
1 paper
NM_002582.4
p.R249G
c.745C>G
1 paper
NM_002582.4
p.E248del1
c.742_743delTTC
1 paper
NM_002582.4
p.R249L
c.746G>T
1 paper
NM_002582.4
p.R249H
c.746G>A
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