Varaico: Literature-Extracted Genetic Variants

Gene:PARN
Variant:p.I239L

PARN

231 papers

RefSeq Summary

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mR...

Pfam Domains

CAF1aa 3–390UCSCCAF1 family ribonuclease
RNA_bindaa 437–515UCSCRNA binding domain

Gene Aliases

HGNC Name

poly(A)-specific ribonuclease

HGNC Alias Symbol

DAN

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_002582.4
p.I239L
c.715A>C
Surrounding Variants
1 paper
NM_002582.4
p.I239L
c.715A>T
2 papers
NM_002582.4
p.I239V
c.715A>G
1 paper
NM_002582.4
p.I239insFs
c.715dupA
1 paper
NM_002582.4
p.I239T
c.716T>C
1 paper
NM_002582.4
p.I239M
c.717A>G
1 paper
NM_002582.4
p.Y238D
c.712T>G
1 paper
NM_002582.4
p.V240I
c.718G>A
1 paper
NM_002582.4
p.R237L
c.710G>T
1 paper
NM_002582.4
p.R237Q
c.710G>A
5 papers
NM_002582.4
p.R237*
c.709C>T
1 paper
NM_002582.4
p.R237G
c.709C>G
1 paper
NM_002582.4
p.I241F
c.721A>T
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."