Varaico: Literature-Extracted Genetic Variants

Gene:PARN
Variant:p.K234_K235Splc

PARN

231 papers

RefSeq Summary

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mR...

Pfam Domains

CAF1aa 3–390UCSCCAF1 family ribonuclease
RNA_bindaa 437–515UCSCRNA binding domain

Gene Aliases

HGNC Name

poly(A)-specific ribonuclease

HGNC Alias Symbol

DAN

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_002582.4
p.K234_K235Splc
c.703-2A>G
Surrounding Variants
1 paper
NM_002582.4
p.K234_K235Splc
c.703-1G>C
1 paper
NM_002582.4
p.K235fs
c.703_704fs
1 paper
NM_002582.4
p.K235N
c.705G>T
1 paper
NM_002582.4
p.K235N
c.705G>C
1 paper
NM_002582.4
p.E236A
c.707A>C
1 paper
NM_002582.4
p.E236D
c.708G>T
1 paper
NM_002582.4
p.E236D
c.708G>C
5 papers
NM_002582.4
p.R237*
c.709C>T
1 paper
NM_002582.4
p.R237G
c.709C>G
1 paper
NM_002582.4
p.R237L
c.710G>T
1 paper
NM_002582.4
p.R237Q
c.710G>A
1 paper
NM_002582.4
p.Y238D
c.712T>G
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