Varaico: Literature-Extracted Genetic Variants

Gene:PARN
Variant:p.E148K

PARN

231 papers

RefSeq Summary

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mR...

Pfam Domains

CAF1aa 3–390UCSCCAF1 family ribonuclease
RNA_bindaa 437–515UCSCRNA binding domain

Gene Aliases

HGNC Name

poly(A)-specific ribonuclease

HGNC Alias Symbol

DAN

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_002582.4
p.E148K
c.442G>A
Surrounding Variants
1 paper
NM_002582.4
p.E148fs
c.442_443fs
1 paper
NM_002582.4
p.E148A
c.443A>C
1 paper
NM_002582.4
p.D147V
c.440A>T
1 paper
NM_002582.4
p.D147fs
c.439_440fs
1 paper
NM_002582.4
p.D147_K149delFs
c.441_445del5
1 paper
NM_002582.4
p.Y146N
c.436T>A
1 paper
NM_002582.4
p.R143_Q145del3
c.427_434del9
3 papers
NM_002582.4
p.R150C
c.448C>T
1 paper
NM_002582.4
p.R150G
c.448C>G
1 paper
NM_002582.4
p.E148_K149delFs
c.444_447del4
1 paper
NM_002582.4
p.R150P
c.449G>C
2 papers
NM_002582.4
p.R150H
c.449G>A
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