Varaico: Literature-Extracted Genetic Variants

Gene:PARN
Variant:p.F74fs

PARN

231 papers

RefSeq Summary

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mR...

Pfam Domains

CAF1aa 3–390UCSCCAF1 family ribonuclease
RNA_bindaa 437–515UCSCRNA binding domain

Gene Aliases

HGNC Name

poly(A)-specific ribonuclease

HGNC Alias Symbol

DAN

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_002582.4
p.F74fs
c.220_221fs
Surrounding Variants
1 paper
NM_002582.4
p.F74L
c.220T>C
3 papers
NM_002582.4
p.G70_F74delFs
c.208_220del13
1 paper
NM_002582.4
p.F74L
c.222T>G
1 paper
NM_002582.4
p.F74F
c.222T>C
1 paper
NM_002582.4
p.F74L
c.222T>A
1 paper
NM_002582.4
p.T73I
c.218C>T
1 paper
NM_002582.4
p.T73S
c.218C>G
1 paper
NM_002582.4
p.T73S
c.217A>T
1 paper
NM_002582.4
p.F74delFs
c.222delA
1 paper
NM_002582.4
p.K75K
c.225G>A
1 paper
NM_002582.4
p.Y76H
c.226T>C
1 paper
NM_002582.4
p.Y76C
c.227A>G
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