Varaico: Literature-Extracted Genetic Variants

Gene:PCF11
Variant:p.T1520A

PCF11

62 papers

RefSeq Summary

The protein encoded by this gene binds to CLP1 to form pre-mRNA cleavage factor IIm. The encoded protein is necessary for efficient Pol II transcription termination and may be involved in degradation ...

Pfam Domains

CIDaa 21–133UCSCCID domain
Pcf11_helicalaa 198–237UCSCPre-mRNA cleavage complex 2 protein Pcf11, alpha-helical domain
PCF11_chargedaa 328–500UCSCPCF11, charged region
PCF11_RFEG_rptaa 763–862UCSCPre-mRNA cleavage complex 2 protein Pcf11, RFEGP repeat
PCF11_RFEG_rptaa 863–962UCSCPre-mRNA cleavage complex 2 protein Pcf11, RFEGP repeat
PCF11_RFEG_rptaa 949–1037UCSCPre-mRNA cleavage complex 2 protein Pcf11, RFEGP repeat

Gene Aliases

HGNC Name

PCF11 cleavage and polyadenylation factor subunit

HGNC Alias Symbol

KIAA0824

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
2 papers
NM_001346413.3
p.T1520A
c.4558A>G
Surrounding Variants
1 paper
NM_001346413.3
p.R1514H
c.4541G>A
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."