phosphodiesterase 1C

Hcam3

phosphodiesterase 1C, calmodulin-dependent (70kD)

phosphodiesterase 1C, calmodulin-dependent 70kDa

Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

Cam-PDE 1C

3'5'-cyclic nucleotide phosphodiesterase N-terminal

This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta. [provided by RefSeq, Jul 2016].

Varaico: Literature-Extracted Genetic Variants

PDE1C

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Alias Symbol