Varaico: Literature-Extracted Genetic Variants

Gene:PDE4B
Variant:p.E435E

PDE4B

105 papers

RefSeq Summary

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and ...

Pfam Domains

PDE4_UCRaa 166–281UCSCPhosphodiesterase 4 upstream conserved regions (UCR)
PDEase_Iaa 405–645UCSC3'5'-cyclic nucleotide phosphodiesterase

Gene Aliases

HGNC Name

phosphodiesterase 4B

HGNC Previous Symbol

DPDE4

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_002600.4
p.E435E
c.1305G>A
Surrounding Variants
1 paper
NM_002600.4
p.D433A
c.1298A>C
1 paper
NM_002600.4
p.H446N
c.1336C>A
1 paper
NM_002600.4
p.F484Y
c.1451T>A
1 paper
NM_002600.4
p.D428_A429Splc
c.1284+8A>G
1 paper
NM_002600.4
p.V420_L421del2
c.1258_1262del6
1 paper
NM_002600.4
p.S417L
c.1250C>T
1 paper
NM_002600.4
p.D512H
c.1534G>C
1 paper
NM_002600.4
p.D413N
c.1237G>A
1 paper
NM_002600.4
p.L395*
c.1184T>A
1 paper
NM_002600.4
p.L395*
c.1184T>G
1 paper
NM_002600.4
p.V514L
c.1540G>T
1 paper
NM_002600.4
p.M519V
c.1555A>G
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