Varaico: Literature-Extracted Genetic Variants

Gene:PDE4B
Variant:p.E729*

PDE4B

105 papers

RefSeq Summary

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and ...

Pfam Domains

PDE4_UCRaa 166–281UCSCPhosphodiesterase 4 upstream conserved regions (UCR)
PDEase_Iaa 405–645UCSC3'5'-cyclic nucleotide phosphodiesterase

Gene Aliases

HGNC Name

phosphodiesterase 4B

HGNC Previous Symbol

DPDE4

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_002600.4
p.E729*
c.2185G>T
Surrounding Variants
3 papers
NM_002600.4
p.S704C
c.2110A>T
3 papers
NM_002600.4
p.S703C
c.2107A>T
1 paper
NM_002600.4
p.E681Q
c.2041G>C
1 paper
NM_002600.4
p.L674Q
c.2021T>A
1 paper
NM_002600.4
p.S661A
c.1981T>G
1 paper
NM_002600.4
p.S659G
c.1975A>G
1 paper
NM_002600.4
p.Q615_V616Splc
c.1845+74G>A
1 paper
NM_002600.4
p.Q615H
c.1845G>C
1 paper
NM_002600.4
p.Q615H
c.1845G>T
1 paper
NM_002600.4
p.V611M
c.1831G>A
1 paper
NM_002600.4
p.R594W
c.1780C>T
1 paper
NM_002600.4
p.E593D
c.1779G>C
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