Varaico: Literature-Extracted Genetic Variants

PDE4D

247 papers

RefSeq Summary

This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transd...

Pfam Domains

PDE4_UCRaa 113–229UCSCPhosphodiesterase 4 upstream conserved regions (UCR)

PDE4_UCRaa 223–339UCSCPhosphodiesterase 4 upstream conserved regions (UCR)

PDEase_Iaa 351–591UCSC3'5'-cyclic nucleotide phosphodiesterase

PDEase_Iaa 461–701UCSC3'5'-cyclic nucleotide phosphodiesterase

Gene Aliases

HGNC Name

phosphodiesterase 4D

HGNC Previous Symbol

DPDE3

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_001104631.2

p.P225L

c.674C>T

NM_001165899.2

p.P164L

c.491C>T

Surrounding Variants

1 paper

NM_001104631.2

p.P225R

c.674C>G

4 papers

NM_001104631.2

p.P225T

c.673C>A

NM_001165899.2

p.P164T

c.490C>A

4 papers

NM_001104631.2

p.F226V

c.676T>G

NM_001165899.2

p.F165V

c.493T>G

4 papers

NM_001104631.2

p.F226C

c.677T>G

NM_001165899.2

p.F165C

c.494T>G

5 papers

NM_001104631.2

p.F226S

c.677T>C

NM_001165899.2

p.F165S

c.494T>C

5 papers

NM_001104631.2

p.T224I

c.671C>T

NM_001165899.2

p.T163I

c.488C>T

8 papers

NM_001104631.2

p.A227S

c.679G>T

NM_006203.5

p.A91S

c.271G>T

NM_001165899.2

p.A166S

c.496G>T

1 paper

NM_001104631.2

p.A227T

c.679G>A

7 papers

NM_001104631.2

p.Q228E

c.682C>G

NM_001165899.2

p.Q167E

c.499C>G

4 papers

NM_001104631.2

p.Q228P

c.683A>C

NM_001165899.2

p.Q167P

c.500A>C

1 paper

NM_001104631.2

p.D220G

c.659A>G

6 papers

NM_001104631.2

p.L230S

c.689T>C

NM_001165899.2

p.L169S

c.506T>C