Varaico: Literature-Extracted Genetic Variants

PDE4D

247 papers

RefSeq Summary

This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transd...

Pfam Domains

PDE4_UCRaa 113–229UCSCPhosphodiesterase 4 upstream conserved regions (UCR)

PDE4_UCRaa 223–339UCSCPhosphodiesterase 4 upstream conserved regions (UCR)

PDEase_Iaa 351–591UCSC3'5'-cyclic nucleotide phosphodiesterase

PDEase_Iaa 461–701UCSC3'5'-cyclic nucleotide phosphodiesterase

Gene Aliases

HGNC Name

phosphodiesterase 4D

HGNC Previous Symbol

DPDE3

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001104631.2

p.G102A

c.305G>C

Surrounding Variants

1 paper

NM_001104631.2

p.G102G

c.306C>G

3 papers

NM_001104631.2

p.R103H

c.308G>A

1 paper

NM_001104631.2

p.A100S

c.298G>T

1 paper

NM_001104631.2

p.R107H

c.320G>A

1 paper

NM_001104631.2

p.A91S

c.271G>T

3 papers

NM_001104631.2

p.A90T

c.268G>A

1 paper

NM_001104631.2

p.P87L

c.260C>T

1 paper

NM_001104631.2

p.P86L

c.257C>T

1 paper

NM_001104631.2

p.R119H

c.356G>A

1 paper

NM_001104631.2

p.P85S

c.253C>T

1 paper

NM_001104631.2

p.A120A

c.360C>T

1 paper

NM_001104631.2

p.P83L

c.248C>T