peroxisomal biogenesis factor 14

Peroxisomal membrane protein PEX14

PTS1 receptor-docking protein

Peroxin-14

Peroxisomal membrane anchor protein PEX14

This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome. [provided by RefSeq, Jul 2008].

Varaico: Literature-Extracted Genetic Variants

PEX14

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name