Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_006218.4

p.G8V

c.23G>T

Surrounding Variants

5 papers

NM_006218.4

p.G8D

c.23G>A

1 paper

NM_006218.4

p.G8A

c.23G>C

1 paper

NM_006218.4

p.G8R

c.22G>C

1 paper

NM_006218.4

p.G8Fs

c.22delinsCATCTTACFs

1 paper

NM_006218.4

p.G8G

c.24T>C

1 paper

NM_006218.4

p.E9_P18del10

c.25_53del30

1 paper

NM_006218.4

p.E9_R19del0

c.25_57del33

1 paper

NM_006218.4

p.G8insFs

c.23dupG

1 paper

NM_006218.4

p.S7S

c.21A>T

1 paper

NM_006218.4

p.G8delFs

c.23delG

3 papers

NM_006218.4

p.E9K

c.25G>A

1 paper

NM_006218.4

p.E9insFs

c.27dupA