Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006218.4

p.L10L

c.30G>T

Surrounding Variants

1 paper

NM_006218.4

p.L10_W11ins1

c.30_31insGGA

1 paper

NM_006218.4

p.W11R

c.31T>A

4 papers

NM_006218.4

p.L10P

c.29T>C

3 papers

NM_006218.4

p.W11R

c.31T>C

2 papers

NM_006218.4

p.W11G

c.31T>G

1 paper

NM_006218.4

p.L10R

c.29T>G

1 paper

NM_006218.4

p.W11delFs

c.33delG

1 paper

NM_006218.4

p.W11_V22del0

c.32_64del33

1 paper

NM_006218.4

p.L10_P18del0

c.30_53del24

1 paper

NM_006218.4

p.L10M

c.28C>A

1 paper

NM_006218.4

p.L10V

c.28C>G

1 paper

NM_006218.4

p.L10_R19del0

c.29_55del27