Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006218.4

p.G12_P18delFs

c.36_52del17

Surrounding Variants

370 papers

NM_006218.4

p.G12D

c.35G>A

182 papers

NM_006218.4

p.G12A

c.35G>C

1 paper

NM_006218.4

p.G12_I13insFs

c.36_37insC

324 papers

NM_006218.4

p.G12V

c.35G>T

1 paper

NM_006218.4

p.G12delins

c.35_36delinsAG

1 paper

NM_006218.4

p.G12_I13delFs

c.36_37delCA

1 paper

NM_006218.4

p.G12_H14del0

c.36_41del6

1 paper

NM_006218.4

p.I13_P17del0

c.37_51del15

1 paper

NM_006218.4

p.G12_I13delins

c.36_37delinsTC

171 papers

NM_006218.4

p.G12S

c.34G>A

129 papers

NM_006218.4

p.G12R

c.34G>C

2 papers

NM_006218.4

p.G12fs

c.34_35fs