Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006218.4

p.H14_L15delins

c.40_44delinsAAGTG

Surrounding Variants

5 papers

NM_006218.4

p.H14N

c.40C>A

1 paper

NM_006218.4

p.H14L

c.41A>T

1 paper

NM_006218.4

p.I13I

c.39C>T

1 paper

NM_006218.4

p.H14_M16del3

c.40_47del9

4 papers

NM_006218.4

p.H14Q

c.42C>A

4 papers

NM_006218.4

p.H14Q

c.42C>G

2 papers

NM_006218.4

p.I13T

c.38T>C

1 paper

NM_006218.4

p.I13delins

c.38_39delinsAG

1 paper

NM_006218.4

p.I13V

c.37A>G

1 paper

NM_006218.4

p.I13delFs

c.38delT

4 papers

NM_006218.4

p.L15V

c.43T>G

1 paper

NM_006218.4

p.L15fs

c.43_44fs