Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_006218.4

p.L15F

c.45G>T

Surrounding Variants

2 papers

NM_006218.4

p.L15F

c.45G>C

1 paper

NM_006218.4

p.M16_P18del3

c.46_53del9

1 paper

NM_006218.4

p.M16V

c.46A>G

1 paper

NM_006218.4

p.L15*

c.44T>A

1 paper

NM_006218.4

p.L15S

c.44T>C

5 papers

NM_006218.4

p.L15W

c.44T>G

1 paper

NM_006218.4

p.M16T

c.47T>C

4 papers

NM_006218.4

p.L15V

c.43T>G

1 paper

NM_006218.4

p.M16R

c.47T>G

1 paper

NM_006218.4

p.L15fs

c.43_44fs

4 papers

NM_006218.4

p.H14Q

c.42C>A

4 papers

NM_006218.4

p.H14Q

c.42C>G