Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006218.4

p.E35V

c.104A>T

Surrounding Variants

1 paper

NM_006218.4

p.E35_L37delFs

c.105_109del5

1 paper

NM_006218.4

p.C36_T41del6

c.106_122del18

1 paper

NM_006218.4

p.E35_C36insFs

c.105_106insGC

1 paper

NM_006218.4

p.C36_L37del2

c.106_110del6

2 papers

NM_006218.4

p.E35K

c.103G>A

2 papers

NM_006218.4

p.E35Q

c.103G>C

1 paper

NM_006218.4

p.E35*

c.103G>T

1 paper

NM_006218.4

p.E35delFs

c.104_105delAA

1 paper

NM_006218.4

p.E35_C36del1

c.104_106delAAT

1 paper

NM_006218.4

p.L34_E35insFs

c.102_103insG

2 papers

NM_006218.4

p.L34F

c.102A>C

1 paper

NM_006218.4

p.L34L

c.102A>G