Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_006218.4

p.C36_L37delFs

c.108_111del4

Surrounding Variants

3 papers

NM_006218.4

p.C36Y

c.107G>A

6 papers

NM_006218.4

p.L37delFs

c.109delC

1 paper

NM_006218.4

p.C36_L37delFs

c.108_109delCC

1 paper

NM_006218.4

p.L37_K51del15

c.109_152del45

1 paper

NM_006218.4

p.E35_C36insFs

c.105_106insGC

1 paper

NM_006218.4

p.C36_L37del2

c.106_110del6

1 paper

NM_006218.4

p.L37I

c.109C>A

3 papers

NM_006218.4

p.L37F

c.109C>T

1 paper

NM_006218.4

p.L37_R38delFs

c.110_114del5

1 paper

NM_006218.4

p.L37_K51del0

c.110_151del42

1 paper

NM_006218.4

p.E35V

c.104A>T

1 paper

NM_006218.4

p.E35_L37delFs

c.105_109del5