Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_006218.4

p.I45delFs

c.134_135delTA

Surrounding Variants

1 paper

NM_006218.4

p.T44T

c.132C>A

1 paper

NM_006218.4

p.T44T

c.132C>T

1 paper

NM_006218.4

p.T44S

c.131C>G

1 paper

NM_006218.4

p.T44I

c.131C>T

1 paper

NM_006218.4

p.T44_I45insFs

c.132_133insC

1 paper

NM_006218.4

p.T44A

c.130A>G

1 paper

NM_006218.4

p.T44S

c.130A>T

1 paper

NM_006218.4

p.K46delFs

c.136_137delAA

1 paper

NM_006218.4

p.I43_T44insFs

c.129_130insT

1 paper

NM_006218.4

p.I43M

c.129A>G

1 paper

NM_006218.4

p.I45M

c.135A>G

1 paper

NM_006218.4

p.I43I

c.129A>T