Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006218.4

p.Q63Q

c.189A>G

Surrounding Variants

1 paper

NM_006218.4

p.Q63H

c.189A>C

1 paper

NM_006218.4

p.Q63H

c.189A>T

1 paper

NM_006218.4

p.D64_S67del4

c.190_200del12

3 papers

NM_006218.4

p.Q63R

c.188A>G

3 papers

NM_006218.4

p.D64N

c.190G>A

1 paper

NM_006218.4

p.D64Y

c.190G>T

3 papers

NM_006218.4

p.Q63K

c.187C>A

1 paper

NM_006218.4

p.Q63E

c.187C>G

1 paper

NM_006218.4

p.Q63*

c.187C>T

2 papers

NM_006218.4

p.D64E

c.192T>A

2 papers

NM_006218.4

p.D64E

c.192T>G

1 paper

NM_006218.4

p.E65del1

c.193_195delGAA