Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006218.4

p.S66F

c.197C>T

Surrounding Variants

1 paper

NM_006218.4

p.S66C

c.197C>G

1 paper

NM_006218.4

p.S66S

c.198T>A

1 paper

NM_006218.4

p.S66P

c.196T>C

1 paper

NM_006218.4

p.S66_S67insG

c.196_200ins3

3 papers

NM_006218.4

p.E65D

c.195A>C

3 papers

NM_006218.4

p.E65D

c.195A>T

1 paper

NM_006218.4

p.S67del1

c.199_200delTCT

1 paper

NM_006218.4

p.S67T

c.199T>A

1 paper

NM_006218.4

p.S67A

c.199T>G

1 paper

NM_006218.4

p.E65A

c.194A>C

1 paper

NM_006218.4

p.E65G

c.194A>G

1 paper

NM_006218.4

p.E65_V71delFs

c.195_211del17