Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_006218.4

p.E85D

c.255A>T

Surrounding Variants

1 paper

NM_006218.4

p.E85D

c.255A>C

1 paper

NM_006218.4

p.E85A

c.254A>C

2 papers

NM_006218.4

p.E85V

c.254A>T

1 paper

NM_006218.4

p.T86insFs

c.257_258insTA

1 paper

NM_006218.4

p.T86_L94del0

c.258_281del24

3 papers

NM_006218.4

p.E85K

c.253G>A

1 paper

NM_006218.4

p.E85Q

c.253G>C

1 paper

NM_006218.4

p.E85fs

c.253_254fs

1 paper

NM_006218.4

p.E85*

c.253G>T

1 paper

NM_006218.4

p.D84E

c.252T>A

1 paper

NM_006218.4

p.D84E

c.252T>G

1 paper

NM_006218.4

p.E85delFs

c.253delG