Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006218.4

p.D91G

c.272A>G

Surrounding Variants

1 paper

NM_006218.4

p.D91D

c.273C>T

1 paper

NM_006218.4

p.D91N

c.271G>A

2 papers

NM_006218.4

p.L92I

c.274C>A

1 paper

NM_006218.4

p.L92_R93insT

c.274_278ins3

1 paper

NM_006218.4

p.L92F

c.274C>T

1 paper

NM_006218.4

p.C90C

c.270T>C

5 papers

NM_006218.4

p.C90Y

c.269G>A

3 papers

NM_006218.4

p.C90R

c.268T>C

3 papers

NM_006218.4

p.C90G

c.268T>G

1 paper

NM_006218.4

p.C90fs

c.268_269fs

3 papers

NM_006218.4

p.R93G

c.277C>G

119 papers

NM_006218.4

p.R93W

c.277C>T