Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006218.4

p.V101A

c.302T>C

Surrounding Variants

3 papers

NM_006218.4

p.V101V

c.303A>G

3 papers

NM_006218.4

p.I102del1

c.304_305delATT

4 papers

NM_006218.4

p.V101I

c.301G>A

2 papers

NM_006218.4

p.V101L

c.301G>C

1 paper

NM_006218.4

p.V101fs

c.301_302fs

2 papers

NM_006218.4

p.V101L

c.301G>T

1 paper

NM_006218.4

p.I102_E103insG

c.304_308ins3

1 paper

NM_006218.4

p.K100N

c.300A>C

3 papers

NM_006218.4

p.I102F

c.304A>T

2 papers

NM_006218.4

p.K100N

c.300A>T

1 paper

NM_006218.4

p.I102delFs

c.306delT

3 papers

NM_006218.4

p.I102_E103del1

c.305_307delTTG