Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

99 papers

NM_006218.4

p.G106V

c.317G>T

Surrounding Variants

5 papers

NM_006218.4

p.G106D

c.317G>A

2 papers

NM_006218.4

p.G106A

c.317G>C

1 paper

NM_006218.4

p.G106delins

c.317_318delinsTT

4 papers

NM_006218.4

p.N107del1

c.319_320delAAC

1 paper

NM_006218.4

p.G106_E110del0

c.318_329del12

1 paper

NM_006218.4

p.G106G

c.318C>A

9 papers

NM_006218.4

p.G106S

c.316G>A

34 papers

NM_006218.4

p.G106R

c.316G>C

8 papers

NM_006218.4

p.G106C

c.316G>T

1 paper

NM_006218.4

p.G106_R108delins

c.316_323delinsAT

3 papers

NM_006218.4

p.N107H

c.319A>C

1 paper

NM_006218.4

p.V105V

c.315A>G