Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_006218.4

p.K111T

c.332A>C

Surrounding Variants

13 papers

NM_006218.4

p.K111R

c.332A>G

1 paper

NM_006218.4

p.K111M

c.332A>T

4 papers

NM_006218.4

p.K111_I112del1

c.333_335delGAT

1 paper

NM_006218.4

p.K111_L113del0

c.333_338del6

4 papers

NM_006218.4

p.K111Q

c.331A>C

172 papers

NM_006218.4

p.K111E

c.331A>G

1 paper

NM_006218.4

p.K111*

c.331A>T

1 paper

NM_006218.4

p.K111fs

c.331_332fs

1 paper

NM_006218.4

p.K111_R115del0

c.332_343del12

125 papers

NM_006218.4

p.K111N

c.333G>C

123 papers

NM_006218.4

p.K111N

c.333G>T

1 paper

NM_006218.4

p.I112del1

c.334_335delATC