Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_006218.4

p.I112T

c.335T>C

Surrounding Variants

14 papers

NM_006218.4

p.I112N

c.335T>A

1 paper

NM_006218.4

p.I112S

c.335T>G

1 paper

NM_006218.4

p.N114ins2

c.341_342ins6

3 papers

NM_006218.4

p.I112V

c.334A>G

4 papers

NM_006218.4

p.I112F

c.334A>T

14 papers

NM_006218.4

p.L113del1

c.337_338delCTC

1 paper

NM_006218.4

p.I112I

c.336C>T

1 paper

NM_006218.4

p.L113_N114del0

c.337_342del6

1 paper

NM_006218.4

p.L113fs

c.337_338fs

1 paper

NM_006218.4

p.L113V

c.337C>G

125 papers

NM_006218.4

p.K111N

c.333G>C

123 papers

NM_006218.4

p.K111N

c.333G>T