Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006218.4

p.G118Splc

c.353-1G>C

Surrounding Variants

78 papers

NM_006218.4

p.G118D

c.353G>A

1 paper

NM_006218.4

p.G118V

c.353G>T

2 papers

NM_006218.4

p.F119I

c.355T>A

1 paper

NM_006218.4

p.A120P

c.358G>C

5 papers

NM_006218.4

p.A120V

c.359C>T

1 paper

NM_006218.4

p.A120A

c.360T>A

2 papers

NM_006218.4

p.I121V

c.361A>G

1 paper

NM_006218.4

p.I121N

c.362T>A

1 paper

NM_006218.4

p.I121M

c.363C>G

3 papers

NM_006218.4

p.I121I

c.363C>T

2 papers

NM_006218.4

p.G122S

c.364G>A

9 papers

NM_006218.4

p.G122D

c.365G>A