Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006218.4

p.V136V

c.408A>T

Surrounding Variants

1 paper

NM_006218.4

p.Q137K

c.409C>A

1 paper

NM_006218.4

p.Q137*

c.409C>T

1 paper

NM_006218.4

p.V136A

c.407T>C

2 papers

NM_006218.4

p.Q137L

c.410A>T

4 papers

NM_006218.4

p.V136I

c.406G>A

1 paper

NM_006218.4

p.E135D

c.405A>C

1 paper

NM_006218.4

p.E135D

c.405A>T

1 paper

NM_006218.4

p.V136_Q137del2

c.406_410del6

1 paper

NM_006218.4

p.Q137H

c.411G>C

1 paper

NM_006218.4

p.Q137H

c.411G>T

1 paper

NM_006218.4

p.E135G

c.404A>G

2 papers

NM_006218.4

p.D138N

c.412G>A