Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006218.4

p.V146F

c.436G>T

Surrounding Variants

29 papers

NM_006218.4

p.V146I

c.436G>A

6 papers

NM_006218.4

p.V146L

c.436G>C

1 paper

NM_006218.4

p.V146_C147insA

c.436_440ins3

1 paper

NM_006218.4

p.N145N

c.435C>T

1 paper

NM_006218.4

p.V146_L153delFs

c.436_458del23

2 papers

NM_006218.4

p.N145S

c.434A>G

1 paper

NM_006218.4

p.N145H

c.433A>C

2 papers

NM_006218.4

p.C147S

c.439T>A

1 paper

NM_006218.4

p.C147R

c.439T>C

2 papers

NM_006218.4

p.C147Y

c.440G>A

1 paper

NM_006218.4

p.L144L

c.432G>T

1 paper

NM_006218.4

p.L144M

c.430C>A