Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006218.4

p.E149*

c.445G>T

Surrounding Variants

3 papers

NM_006218.4

p.E149K

c.445G>A

1 paper

NM_006218.4

p.E149Q

c.445G>C

1 paper

NM_006218.4

p.E149_D152delFs

c.446_455del10

1 paper

NM_006218.4

p.K148N

c.444A>C

2 papers

NM_006218.4

p.E149G

c.446A>G

1 paper

NM_006218.4

p.E149_A150insFs

c.447_448ins4

1 paper

NM_006218.4

p.A150T

c.448G>A

1 paper

NM_006218.4

p.A150_D152delFs

c.449_455del7

2 papers

NM_006218.4

p.C147Y

c.440G>A

1 paper

NM_006218.4

p.A150A

c.450T>A

1 paper

NM_006218.4

p.V151_D152del1

c.452_454delTGG

1 paper

NM_006218.4

p.V151M

c.451G>A