Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_006218.4

p.S275S

c.825C>T

Surrounding Variants

2 papers

NM_006218.4

p.S275N

c.824G>A

2 papers

NM_006218.4

p.S275C

c.823A>T

1 paper

NM_006218.4

p.C276*

c.828T>A

1 paper

NM_006218.4

p.I277V

c.829A>G

3 papers

NM_006218.4

p.R274K

c.821G>A

1 paper

NM_006218.4

p.R274delFs

c.821delG

1 paper

NM_006218.4

p.R274delins

c.820delinsA

2 papers

NM_006218.4

p.I273T

c.818T>C

3 papers

NM_006218.4

p.I273V

c.817A>G

1 paper

NM_006218.4

p.M278I

c.834G>A

1 paper

NM_006218.4

p.M278I

c.834G>C

1 paper

NM_006218.4

p.M278I

c.834G>T