Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006218.4

p.M278I

c.834G>A

Surrounding Variants

1 paper

NM_006218.4

p.M278I

c.834G>C

1 paper

NM_006218.4

p.M278I

c.834G>T

1 paper

NM_006218.4

p.L279I

c.835C>A

1 paper

NM_006218.4

p.L279insFs

c.835_836insA

1 paper

NM_006218.4

p.L279V

c.835C>G

1 paper

NM_006218.4

p.L279F

c.835C>T

1 paper

NM_006218.4

p.G280R

c.838G>A

1 paper

NM_006218.4

p.G280_R281insTTT

c.838_842ins9

1 paper

NM_006218.4

p.I277V

c.829A>G

5 papers

NM_006218.4

p.G280A

c.839G>C

2 papers

NM_006218.4

p.G280V

c.839G>T

1 paper

NM_006218.4

p.C276*

c.828T>A