Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_006218.4

p.L287F

c.861G>T

Surrounding Variants

1 paper

NM_006218.4

p.L287L

c.859T>C

1 paper

NM_006218.4

p.M288T

c.863T>C

1 paper

NM_006218.4

p.M288delFs

c.864delG

1 paper

NM_006218.4

p.M286I

c.858G>A

1 paper

NM_006218.4

p.M286I

c.858G>C

1 paper

NM_006218.4

p.M286I

c.858G>T

7 papers

NM_006218.4

p.A289T

c.865G>A

1 paper

NM_006218.4

p.M286T

c.857T>C

3 papers

NM_006218.4

p.A289D

c.866C>A

11 papers

NM_006218.4

p.A289V

c.866C>T

1 paper

NM_006218.4

p.A289delFs

c.867delT

1 paper

NM_006218.4

p.L285L

c.855G>A