Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_006218.4

p.S312F

c.935C>T

Surrounding Variants

1 paper

NM_006218.4

p.S312Y

c.935C>A

1 paper

NM_006218.4

p.T313delFs

c.937delA

1 paper

NM_006218.4

p.A314_P316del3

c.940_947del9

1 paper

NM_006218.4

p.T313K

c.938C>A

1 paper

NM_006218.4

p.I311T

c.932T>C

1 paper

NM_006218.4

p.S312_A314del3

c.934_941del9

1 paper

NM_006218.4

p.S312_S323del12

c.934_968del36

1 paper

NM_006218.4

p.T313_A314ins1

c.939_940insAAG

3 papers

NM_006218.4

p.I311V

c.931A>G

1 paper

NM_006218.4

p.I311del1

c.931_932delATT

1 paper

NM_006218.4

p.I311_P316del6

c.931_947del18

1 paper

NM_006218.4

p.A314T

c.940G>A