Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_006218.4

p.M318insFs

c.952_953insA

Surrounding Variants

2 papers

NM_006218.4

p.M318V

c.952A>G

2 papers

NM_006218.4

p.Y317F

c.950A>T

1 paper

NM_006218.4

p.M318_V329del12

c.952_986del36

1 paper

NM_006218.4

p.M318K

c.953T>A

1 paper

NM_006218.4

p.M318T

c.953T>C

1 paper

NM_006218.4

p.Y317insFs

c.949_950insA

1 paper

NM_006218.4

p.Y317_W328del12

c.949_983del36

1 paper

NM_006218.4

p.M318I

c.954G>A

2 papers

NM_006218.4

p.M318I

c.954G>C

1 paper

NM_006218.4

p.M318I

c.954G>T

2 papers

NM_006218.4

p.N319Y

c.955A>T

1 paper

NM_006218.4

p.P316Q

c.947C>A