Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_006218.4

p.K337_L339del3

c.1009_1016del9

Surrounding Variants

1 paper

NM_006218.4

p.I336insFs

c.1007_1008insA

1 paper

NM_006218.4

p.I336fs

c.1006_1007fs

1 paper

NM_006218.4

p.K337R

c.1010A>G

1 paper

NM_006218.4

p.R335S

c.1005A>C

1 paper

NM_006218.4

p.K337N

c.1011A>C

1 paper

NM_006218.4

p.R335R

c.1005A>G

1 paper

NM_006218.4

p.R335S

c.1005A>T

1 paper

NM_006218.4

p.K337N

c.1011A>T

1 paper

NM_006218.4

p.I336_D350del15

c.1006_1049del45

1 paper

NM_006218.4

p.I338_Y343del6

c.1012_1028del18

2 papers

NM_006218.4

p.I338insFs

c.1012_1013insT

2 papers

NM_006218.4

p.I338V

c.1012A>G