Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006218.4

p.C340G

c.1018T>G

Surrounding Variants

1 paper

NM_006218.4

p.C340F

c.1019G>T

1 paper

NM_006218.4

p.L339_A341delFs

c.1017_1021del5

10 papers

NM_006218.4

p.L339I

c.1015C>A

1 paper

NM_006218.4

p.L339insFs

c.1016dupT

1 paper

NM_006218.4

p.L339V

c.1015C>G

4 papers

NM_006218.4

p.L339F

c.1015C>T

1 paper

NM_006218.4

p.L339_C340delFs

c.1017_1018delTT

1 paper

NM_006218.4

p.A341_T342ins6

c.1021_1025ins18

2 papers

NM_006218.4

p.A341insFs

c.1022_1023insT

5 papers

NM_006218.4

p.A341V

c.1022C>T

2 papers

NM_006218.4

p.T342delFs

c.1024delA

1 paper

NM_006218.4

p.A341_T342insFs

c.1023_1024ins4