Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006218.4

p.T342delFs

c.1025delC

Surrounding Variants

1 paper

NM_006218.4

p.T342P

c.1024A>C

1 paper

NM_006218.4

p.T342fs

c.1024_1025fs

1 paper

NM_006218.4

p.A341_T342insFs

c.1023_1024ins4

1 paper

NM_006218.4

p.T342insFs

c.1025_1026insTA

2 papers

NM_006218.4

p.T342I

c.1025C>T

2 papers

NM_006218.4

p.T342T

c.1026C>A

2 papers

NM_006218.4

p.A341insFs

c.1022_1023insT

5 papers

NM_006218.4

p.A341V

c.1022C>T

1 paper

NM_006218.4

p.T342T

c.1026C>T

2 papers

NM_006218.4

p.T342delFs

c.1024delA

1 paper

NM_006218.4

p.A341_T342ins6

c.1021_1025ins18

8 papers

NM_006218.4

p.Y343C

c.1028A>G