Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_006218.4

p.Y361C

c.1082A>G

Surrounding Variants

1 paper

NM_006218.4

p.H362N

c.1084C>A

1 paper

NM_006218.4

p.H362Y

c.1084C>T

1 paper

NM_006218.4

p.I360V

c.1078A>G

1 paper

NM_006218.4

p.G359D

c.1076G>A

8 papers

NM_006218.4

p.G363A

c.1088G>C

1 paper

NM_006218.4

p.G359A

c.1076G>C

1 paper

NM_006218.4

p.G359V

c.1076G>T

2 papers

NM_006218.4

p.G359R

c.1075G>C

47 papers

NM_006218.4

p.G364R

c.1090G>A

47 papers

NM_006218.4

p.G364R

c.1090G>C

2 papers

NM_006218.4

p.T358R

c.1073C>G

1 paper

NM_006218.4

p.T358I

c.1073C>T