Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

47 papers

NM_006218.4

p.G364R

c.1090G>A

Surrounding Variants

47 papers

NM_006218.4

p.G364R

c.1090G>C

2 papers

NM_006218.4

p.G364E

c.1091G>A

1 paper

NM_006218.4

p.E365_P366delFs

c.1093_1096del4

8 papers

NM_006218.4

p.G363A

c.1088G>C

109 papers

NM_006218.4

p.E365K

c.1093G>A

8 papers

NM_006218.4

p.E365V

c.1094A>T

1 paper

NM_006218.4

p.E365D

c.1095A>C

1 paper

NM_006218.4

p.E365D

c.1095A>T

1 paper

NM_006218.4

p.H362N

c.1084C>A

2 papers

NM_006218.4

p.P366A

c.1096C>G

1 paper

NM_006218.4

p.H362Y

c.1084C>T

1 paper

NM_006218.4

p.P366H

c.1097C>A