Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006218.4

p.Y392*

c.1176C>A

Surrounding Variants

1 paper

NM_006218.4

p.Y392*

c.1176C>G

1 paper

NM_006218.4

p.Y392Y

c.1176C>T

1 paper

NM_006218.4

p.I393_D395del3

c.1177_1184del9

1 paper

NM_006218.4

p.Y392C

c.1175A>G

1 paper

NM_006218.4

p.Y392F

c.1175A>T

1 paper

NM_006218.4

p.Y392N

c.1174T>A

1 paper

NM_006218.4

p.I393N

c.1178T>A

1 paper

NM_006218.4

p.Y392H

c.1174T>C

1 paper

NM_006218.4

p.I393T

c.1178T>C

140 papers

NM_006218.4

p.I391M

c.1173A>G

1 paper

NM_006218.4

p.P394S

c.1180C>T

1 paper

NM_006218.4

p.I391K

c.1172T>A