Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006218.4

p.L402insFs

c.1205_1206insT

Surrounding Variants

1 paper

NM_006218.4

p.L402V

c.1204C>G

1 paper

NM_006218.4

p.L402F

c.1204C>T

2 papers

NM_006218.4

p.L402R

c.1205T>G

4 papers

NM_006218.4

p.R401Q

c.1202G>A

4 papers

NM_006218.4

p.R401*

c.1201C>T

1 paper

NM_006218.4

p.C403S

c.1207T>A

1 paper

NM_006218.4

p.C403G

c.1207T>G

1 paper

NM_006218.4

p.C403_L404ins4

c.1207_1211ins12

1 paper

NM_006218.4

p.C403S

c.1208G>C

1 paper

NM_006218.4

p.C403delFs

c.1209delC

10 papers

NM_006218.4

p.A400V

c.1199C>T

1 paper

NM_006218.4

p.A400P

c.1198G>C