Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006218.4

p.N444K

c.1332T>G

Surrounding Variants

1 paper

NM_006218.4

p.N444K

c.1332T>A

1 paper

NM_006218.4

p.L445delFs

c.1333_1334delCT

1 paper

NM_006218.4

p.L445_W446delFs

c.1333_1336del4

2 papers

NM_006218.4

p.L445I

c.1333C>A

2 papers

NM_006218.4

p.L445F

c.1333C>T

1 paper

NM_006218.4

p.N444Y

c.1330A>T

1 paper

NM_006218.4

p.L445P

c.1334T>C

2 papers

NM_006218.4

p.L443L

c.1329G>A

1 paper

NM_006218.4

p.W446_L455del10

c.1336_1364del30

1 paper

NM_006218.4

p.W446R

c.1336T>A

2 papers

NM_006218.4

p.L443S

c.1328T>C

1 paper

NM_006218.4

p.W446R

c.1336T>C