Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006218.4

p.F550L

c.1650T>A

Surrounding Variants

1 paper

NM_006218.4

p.F550L

c.1650T>G

2 papers

NM_006218.4

p.L551I

c.1651C>A

3 papers

NM_006218.4

p.L551V

c.1651C>G

3 papers

NM_006218.4

p.L551L

c.1651C>T

1 paper

NM_006218.4

p.F550S

c.1649T>C

1 paper

NM_006218.4

p.L551Q

c.1652T>A

1 paper

NM_006218.4

p.F550L

c.1648T>C

1 paper

NM_006218.4

p.F550_L551insC

c.1648_1652ins3

1 paper

NM_006218.4

p.D549E

c.1647T>A

2 papers

NM_006218.4

p.D549E

c.1647T>G

1 paper

NM_006218.4

p.F550_H554del5

c.1648_1661del15

2 papers

NM_006218.4

p.D549A

c.1646A>C