Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006218.4

p.L686L

c.2056C>T

Surrounding Variants

1 paper

NM_006218.4

p.L686M

c.2056C>A

1 paper

NM_006218.4

p.G685G

c.2055C>G

1 paper

NM_006218.4

p.L686Q

c.2057T>A

2 papers

NM_006218.4

p.L686R

c.2057T>G

1 paper

NM_006218.4

p.L686delins

c.2057_2058delinsGA

2 papers

NM_006218.4

p.G685D

c.2054G>A

1 paper

NM_006218.4

p.G685A

c.2054G>C

1 paper

NM_006218.4

p.L686L

c.2058G>C

1 paper

NM_006218.4

p.G685V

c.2054G>T

2 papers

NM_006218.4

p.L687I

c.2059C>A

1 paper

NM_006218.4

p.L687_L688insG

c.2059_2063ins3

1 paper

NM_006218.4

p.G685S

c.2053G>A