Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006218.4

p.A775T

c.2323G>A

Surrounding Variants

2 papers

NM_006218.4

p.A775S

c.2323G>T

1 paper

NM_006218.4

p.A775insFs

c.2324_2325ins8

1 paper

NM_006218.4

p.A775ins4

c.2324_2325ins12

1 paper

NM_006218.4

p.A775V

c.2324C>T

1 paper

NM_006218.4

p.S774_A775ins4

c.2322_2323ins12

1 paper

NM_006218.4

p.S774F

c.2321C>T

1 paper

NM_006218.4

p.K776ins1

c.2326_2327insTAT

1 paper

NM_006218.4

p.K776ins1

c.2326_2327insTCT

1 paper

NM_006218.4

p.K776ins1

c.2326_2327insTGT

2 papers

NM_006218.4

p.K776E

c.2326A>G

1 paper

NM_006218.4

p.S774ins2

c.2320_2321ins6

1 paper

NM_006218.4

p.S774ins2

c.2320_2321ins6