Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006218.4

p.I799T

c.2396T>C

Surrounding Variants

2 papers

NM_006218.4

p.I799V

c.2395A>G

1 paper

NM_006218.4

p.I799F

c.2395A>T

39 papers

NM_006218.4

p.I800L

c.2398A>C

1 paper

NM_006218.4

p.I799delFs

c.2395delA

1 paper

NM_006218.4

p.E798V

c.2393A>T

1 paper

NM_006218.4

p.I800insFs

c.2399_2400insA

3 papers

NM_006218.4

p.I800M

c.2400C>G

1 paper

NM_006218.4

p.E798Q

c.2392G>C

1 paper

NM_006218.4

p.F801fs

c.2401_2402fs

1 paper

NM_006218.4

p.N797I

c.2390A>T

1 paper

NM_006218.4

p.F801C

c.2402T>G

1 paper

NM_006218.4

p.K802T

c.2405A>C